Ulcer DiseaseNSAIDs
Peptic Ulcer Disease (PUD) is a prevalent gastrointestinal condition characterized by open sores or ulcers in the lining of the stomach or the upper part of the small intestine. These ulcers can cause discomfort, pain, and various complications. One significant factor contributing to the development and exacerbation of peptic ulcers is the indiscriminate use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Examples of commonly used NSAIDS are Ibuprofen, Diclofenac, Piroxicam(Feldene) etc.
NSAIDs are a class of medications widely used to relieve pain, reduce inflammation, and lower fever. They work by inhibiting an enzyme called cyclooxygenase (COX), which is involved in the production of substances that reduce inflammation and pain. While NSAIDs provide effective relief for numerous conditions, their prolonged use can lead to harmful effects on the gastrointestinal tract. Because NSAIDS are drugs sold without prescriptions(OTC) they are widely and readily available to the public. This has lead to self medication and use without proper medical advice or supervision.
One of the mechanisms through which NSAIDs cause peptic ulcers is by disrupting the delicate balance in the stomach. The stomach lining is protected by a mucous layer and various chemicals that regulate acid production. NSAIDs interfere with these protective mechanisms, reducing the production of mucous and bicarbonate while increasing stomach acid secretion. This imbalance weakens the stomach’s defense, making it more susceptible to the harmful effects of gastric acid, ultimately resulting in the development of ulcers.
These ulcers can be painful, cause bleeding, and in severe cases, result in complications like perforation, where the ulcer creates a hole in the gastrointestinal wall and subsequent bleeding. This can also progress to cancer if left unchecked.
It is vital for individuals, especially those with a history of peptic ulcers or gastrointestinal issues, to use NSAIDs cautiously and under the guidance of a healthcare professional. If NSAIDs are deemed necessary, doctors usually prescribe the lowest effective dose for the shortest duration possible. In other cases drugs that are entirely from a different class are used to achieve pain and inflammatory control, and in other scenarios NSAIDS combined with drugs that prevent the development of ulcers are used. The bottom line being it is vital people seek professional advise before self medication.
Lastly some very important things to note are:
– Avoid unnecessary use of NSAIDs
– Use the smallest effective dose, if NSAIDs must be used.
– NSAIDS are the not the only drugs used to treat pain, inflammation or fevers.
They are not to be used for more than 3 days consecutively without consulting a doctor. * Do not exceed the recommended doses in an effort to feel better faster.
Do not take them on empty stomach (ensure you eat before)
– Tell your medical providers if you have peptic ulcers or have a history of ulcer.
– Do not self medicate!
Thank you
Pharm Maryam Aminu
